In order to avoid security-related warning messages when switching to secured connection, you may want either to:

Click here to proceed.

Welcome to SwissSidechain!


SwissSidechain is a structural and molecular mechanics database of hundreds of non-natural amino-acid sidechains that can be used to study in silico their insertion into natural peptides or proteins.

Structural files (pdb, mol2, SMILES) for 230 sidechains (both D and L) can be found together with PyMOL and UCSF Chimera plugins to insert them into existing peptide or protein structures. Predicted rotamers as well as topologies and parameters to run molecular mechanics analysis are provided. The description of the different methods used to generate these data can be found in our paper.


This website is provided and maintained by the Molecular modeling group at the Swiss Institute of Bioinformatics. This database is free for academic use. For commercial license agreement, please see our license policy.

How to cite: SwissSidechain: a molecular and structural database of non-natural sidechains
Gfeller D, Michielin O, Zoete V; Nucleic Acids Research, 41, D327-D332 (2013) (PDF).